Journal of the South African Veterinary Association
On-line version ISSN 2224-9435
Print version ISSN 1019-9128
FATTAHIAN, Hamidreza et al. Immunohistochemical study of a canine neurofibroma. J. S. Afr. Vet. Assoc. [online]. 2012, vol.83, n.1, pp.55-59. ISSN 2224-9435.
Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.