SciELO - Scientific Electronic Library Online

 
vol.83 issue1Morbidity and mortality following envenomation by the common night adder (Causus rhombeatus) in three dogsAvian bornavirus genotype 4 recovered from naturally infected psittacine birds with proventricular dilatation disease in South Africa author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Journal of the South African Veterinary Association

On-line version ISSN 2224-9435

Abstract

LOBETTI, Remo G.  and  CALDWELL, Peter. Doramectin toxicity in a group of lions (Panthera leo). J. S. Afr. Vet. Assoc. [online]. 2012, vol.83, n.1, pp. 89-92. ISSN 2224-9435.

Ten lions (Panthera leo) that were treated with a single injection of doramectin at a dose ranging between 0.2 mg/kg and 0.5 mg/kg showed clinical signs consistent with avermectin toxicity, namely ataxia, hallucinations, and mydriasis. Two subsequently died whereas the other eight lions recovered after 4-5 days with symptomatic therapy. Post-mortem examinations of the two that died showed cyanosis, severe pulmonary oedema, pleural effusion, and pericardial effusion, with histopathology not revealing any abnormalities. In both these lions, doramectin brain and liver tissue concentrations were elevated. Although doramectin is regularly used in wild felids, to date there have been no reports of avermectin toxicity in the literature. This article highlights the potential for doramectin toxicity in this species.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License