Resumo

BAKHERAD, Mohammad; KEIVANLOO, Ali; BAJESTANI, Mahsa Abedi  e  REZAEIFARD, Amin. Green synthesis of chromeno[2,3-c]pyrazoles and 4,4'-(arylmethylene)bis(1H-pyrazole-5-ols) via catalyst-free multicomponent reaction in magnetized distilled water. S.Afr.j.chem. (Online) [online]. 2023, vol.77, pp.171-177. ISSN 1996-840X.  http://dx.doi.org/10.17159/0379-4350/2023/v77a22.

An eco-friendly benign catalyst-free synthesis of chromeno[2,3-c]pyrazoles and bis-pyrazolone derivatives has been reported using magnetized distilled water (MDW). Under the optimal condition, most chromeno[2,3-c]pyrazoles (5a-f) and bis-pyrazolone (7a-k) were obtained in 85-93% and 85-95% yields respectively. This process offers several advantages, including its environmentally friendly and cost-effective nature, along with a simplified workup procedure and a high yield of desired products. Additionally, the absence of catalysts minimizes the potential for undesirable side reactions and contamination, resulting in a cleaner and more efficient synthesis process.

Palavras-chave : Chromeno[2,3-c]pyrazole; Bis-pyrazolone; Catalyst-free; Magnetized distilled water.

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