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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350


BELHADJ, Fatima et al. Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines. S.Afr.j.chem. (Online) [online]. 2021, vol.75, pp.150-155. ISSN 1996-840X.

A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations and solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H and 13C NMR analysis. Additionally, the synthesised compounds were investigated for their antibacterial and antioxidant potential. Compounds 3b, 3c, 3e, 4c and 4e showed significant activities.

Keywords : 5H-chromeno[2,3-d] pyrimidine; 4H-chromene; solvent-free conditions; antioxidant activity; antibacterial activity.

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