Abstract

PANSURIYA, Pramod B.; MAGUIRE, Glenn E.M.  and  FRIEDRICH, Holger B.. Structural Characterization and Thermal Properties of the Anti-malarial Drug: Lumefantrine. S.Afr.j.chem. (Online) [online]. 2019, vol.72, pp.253-262. ISSN 1996-840X.  http://dx.doi.org/10.17159/0379-4350/2019/v72a33.

The anti-malarial lumefantrine was characterized in the solid as well as the solution state. The solid state analysis was carried out by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), DSC, TG-DTG and ATR-IR. The single crystal structure of lumefantrine has been solved. The structure is stabilized via inter- as well as intra-C-H...Cl interactions, intra hydrogen bonding O-H.. .N interactions and C-H.. .O weak interactions. The Hirshfeld surface intermolecular interactions have been studied using the crystal structure. Solution structure analyses have been done by NMR, COSY/NOESY, HSQC and mass spectrometry. The thermal properties were studied by solid-state differential scanning calorimetry and thermogravimetric analysis of the drug under nitrogen as well as in air.

Keywords : Single crystal structure; lumefantrine; 2D NMR; DSC; PXRD.

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