SciELO - Scientific Electronic Library Online

 
vol.70Synthesis and photocatalytic activity of monolithic Fe2O3/TiO2Effects of precursor salt on colloidal cobalt oxyhydroxides composition and its application in non-enzymatic glucose author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • On index processSimilars in Google

Share


South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

Abstract

KHALAFY, Jabbar et al. Synthesis of some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione derivatives by a one-pot, three-component reaction. S.Afr.j.chem. (Online) [online]. 2017, vol.70, pp.132-136. ISSN 1996-840X.  http://dx.doi.org/10.17159/0379-4350/2017/v70a19.

This study reports the reduction of α,β-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl ]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.

Keywords : Arylglyoxals; L-cysteine; 1,3-dimethylbarbituric acid; phosphotungstic acid; one-pot; multi-component reaction.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License