SciELO - Scientific Electronic Library Online

 
vol.69Organocatalyzed Mannich Reactions on Minocycline: Towards Novel Tetracycline AntibioticsA Review of using spray pyrolysis through Sol-gel materials in the synthesis of cathode materials for lithium-ion batteries author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • On index processSimilars in Google

Share


South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

Abstract

HADI, Mojtaba  and  EHSANI, Ali. Anodized Edge-plane Pyrolytic Graphite for Electroanalysis of Pantoprazole in Tablet Dosage Forms and Human Urine Samples. S.Afr.j.chem. (Online) [online]. 2016, vol.69, pp.79-87. ISSN 1996-840X.  http://dx.doi.org/10.17159/0379-4350/2016/v69a10.

Electroanalytical parameters of different graphitic carbon-based electrode materials were compared to select the best one for the pantoprazole electroanalysis. Such parameters include sensitivity, repeatability, residual background current, and signal-to-background current ratio of the analytical response and such electrodes include conventional carbon-based electrodes such as glassy carbon (GC), carbon paste, edge-plane pyrolytic graphite (EPPG), and basal-plane pyrolytic graphite electrodes and film-coated modified GC electrodes with graphitic carbon-based materials such as carbon nanotube, nanographene, carbon black and graphite powder. The EPPG electrode, after applying a simple electrochemical anodization, showed more acceptable analytical performances compared with the other electrodes. Raman spectroscopy was employed to study the surface structural changes that occurred dring the anodic activation. Calibration plot with a good linearity was obtained in the concentration range of 0.2-25 and 0.02-8.5 μΜ, and the detection limit was estimated to be 0.055 and 0.0041 μΜ using cyclic voltammetry and differential pulse voltammetry techniques, respectively. Finally, the electrochemically activated EPPG electrode was used successfully for the determination of pantoprazole in tablet dosage forms and human urine samples with satisfactory results.

Keywords : Edge-plane pyrolytic graphite; graphitic carbon-based electrodes; anodic activation; pantoprazole electroanalysis; nano-graphene; carbon nanotube.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License