SciELO - Scientific Electronic Library Online

vol.69Speciation of Chromium and Vanadium in Medicinal PlantsAnodized Edge-plane Pyrolytic Graphite for Electroanalysis of Pantoprazole in Tablet Dosage Forms and Human Urine Samples author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • On index processSimilars in Google


South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350


CHIWUNZE, Tirivashe E. et al. Organocatalyzed Mannich Reactions on Minocycline: Towards Novel Tetracycline Antibiotics. S.Afr.j.chem. (Online) [online]. 2016, vol.69, pp.72-78. ISSN 1996-840X.

Herein, we report the development of a mild synthetic route towards novel minocycline derivatives using the proline-catalyzed three-component Mannich reaction. The reaction conditions were optimized and was then screened for its tolerance to the other popular organocatalysts as well as variation of the ketone and aldehyde substrates. The Mannich adducts were evaluated for their in vitro antibacterial efficacies against Gram-negative and Gram-positive bacteria.

Keywords : Minocycline; tetracycline; antibiotics; Mannich reaction; organocatalysis.

        · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License