Resumo

GOVENDER, Thavendran et al. In vitro Investigation of the Antimicrobial Activity of a Series of Lipophilic Phenols and Naphthols. S.Afr.j.chem. (Online) [online]. 2016, vol.69, pp.44-50. ISSN 1996-840X.  http://dx.doi.org/10.17159/0379-4350/2016/v69a6.

Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

Palavras-chave : Antimicrobial activity; phenols; naphthols; quinone methides.

        · texto em Inglês     · Inglês ( pdf )