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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350


GOVENDER, Thavendran et al. In vitro Investigation of the Antimicrobial Activity of a Series of Lipophilic Phenols and Naphthols. S.Afr.j.chem. (Online) [online]. 2016, vol.69, pp.44-50. ISSN 1996-840X.

Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

Keywords : Antimicrobial activity; phenols; naphthols; quinone methides.

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