South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
OTOKESH, Somayeh et al. A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid. S.Afr.j.chem. (Online) [online]. 2015, vol.68, pp.15-20. ISSN 1996-840X. http://dx.doi.org/10.17159/0379-4350/2015/v68a3.
A simple and efficient procedure for the synthesis of polyhydroquinolines was developed, involving a one-pot four-component Hantzsch condensation of aromatic aldehydes, 1,3-cyclohexanediones, alkyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanomagnetic-supported sulfonic acid under solvent-free conditions. The method offers several advantages including high yields, short reaction times, a simple work-up procedure and catalyst reusability for several runs. Furthermore, easy isolation of the catalyst from the reaction mixture was enabled by use of an external magnet.
Keywords : Nanomagnetic-supported sulfonic acid; multicomponent reaction; solvent-free conditions; heterocyclic compound; Hantzsch reaction.