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South African Journal of Chemistry

versão On-line ISSN 1996-840X

Resumo

CHAKRAVORTY, Santanu et al. Synthesis of Novel Piperazine-linked Anthranilic Acids as Potential Small Molecule Kinase Inhibitors. S.Afr.j.chem. (Online) [online]. 2014, vol.67, pp. 0-0. ISSN 1996-840X.

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamide-piperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.

Palavras-chave : Small molecule kinase inhibitors; anthranilic acid; piperazines; EGFR.

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