South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
SAFAEI-GHOMI, Javad and GHASEMZADEH, Mohammad Ali. A simple and efficient synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones by ZnO nanoparticles catalyzed three component coupling reaction of aldehydes, 2-naphthol and dimedone. S.Afr.j.chem. (Online) [online]. 2014, vol.67, pp.27-32. ISSN 1996-840X.
Highly effective zinc oxide nanoparticles catalyzed solvent-free synthesis of some tetrahydrobenzo[a]xanthen-11-one derivatives via one-pot multi-component reaction of aldehydes, 2-naphthol and dimedone. The present approach creates a variety of biologically active heterocyclic compounds in excellent yields and short reaction times. Four new compounds are reported. The salient features of the ZnO nanoparticles are: easy preparation, cost-effective, high stability, low loading and reusability of the catalyst. The prepared zinc oxide nanoparticles were fully characterized by EDX, XRD, SEM, IR and TEM analysis.
Keywords : ZnO; nanoparticles; tetrahydrobenzo[a]xanthen-11-one; multi-component reactions; heterocyclic compounds.