Abstract

MIRJALILI, Bi Bi Fatemeh  and  ZAMANI, Leila. Nano-TiCl₄.SiO₂: a versatile and efficient catalyst for synthesis of dihydropyrimidones via Biginelli condensation. S.Afr.j.chem. (Online) [online]. 2014, vol.67, pp.21-26. ISSN 1996-840X.

Nano-TiCl₄.SiO₂ has been found to be an extremely efficient catalyst for the preparation of 3,4-dihydropyrimidinones/thiones via three-component reactions of an aldehyde, β-ketoester or β-diketone and urea or thiourea under mild conditions. Nano-TiCl₄.SiO₂ as a solid Lewis acid has been synthesized by reaction of nano-SiO₂ and TiCl₄. The structural characterization of this acid has been studied by FT-IR (ATR), XRD, SEM and TEM. This process was simple and environmentally benign with high to excellent yields. Furthermore, the catalyst could be recovered conveniently and reused for at least three times.

Keywords : Nano-TiCl₄.SiO₂; heterogeneous catalyst; multi-component reaction; β-ketoester; β-diketone; urea.

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