South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
SAEED, Aamer; ABBAS, Naeem; ASHRAF, Zaman and BOLTE, Michael. Synthesis, Characterization and Antibacterial Activity of New 1,2- and 1,4-Bis(N' -Substituted Thioureido)benzene Derivatives. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp.273-278. ISSN 1996-840X.
Synthesis of two series of 1,2- and 1,4-bis(thioureido)benzene derivatives was accomplished by the treatment of corresponding alkanoyl/aroyl chlorides with potassium thiocyanate in dry acetone to afford the respective isothiocyanates as intermediates. The latter were treated in situ with 1,2- and 1,4-diaminobenzene, respectively, to afford the title compounds in high yields. A total of sixteen new compounds are reported herein. The structures of the products were confirmed by spectroscopic techniques (IR, 1H and 13C NMR, mass spectrometry), elemental analysis and in case of 1d, by X-ray diffraction technique. All the synthesized compounds were also subjected to antibacterial bioevaluation against ten different Gram-positive and Gram-negative bacterial strains using levofloxacin as the standard drug and were shown to possess promising activities.
Keywords : Bis(thioureido)benzene; antibacterial activity; crystal structure.