Abstract

SAEED, Aamer; ABBAS, Naeem; ASHRAF, Zaman  and  BOLTE, Michael. Synthesis, Characterization and Antibacterial Activity of New 1,2- and 1,4-Bis(N' -Substituted Thioureido)benzene Derivatives. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp.273-278. ISSN 1996-840X.

Synthesis of two series of 1,2- and 1,4-bis(thioureido)benzene derivatives was accomplished by the treatment of corresponding alkanoyl/aroyl chlorides with potassium thiocyanate in dry acetone to afford the respective isothiocyanates as intermediates. The latter were treated in situ with 1,2- and 1,4-diaminobenzene, respectively, to afford the title compounds in high yields. A total of sixteen new compounds are reported herein. The structures of the products were confirmed by spectroscopic techniques (IR, ¹H and ¹³C NMR, mass spectrometry), elemental analysis and in case of 1d, by X-ray diffraction technique. All the synthesized compounds were also subjected to antibacterial bioevaluation against ten different Gram-positive and Gram-negative bacterial strains using levofloxacin as the standard drug and were shown to possess promising activities.

Keywords : Bis(thioureido)benzene; antibacterial activity; crystal structure.

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