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South African Journal of Chemistry

versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350

Resumo

SIDDIQUI, Naqui-Jahan; IDREES, Mohammad; KHATI, N.T.  e  DHONDE, M. G.. Synthesis and Antimicrobial Activities of Some New Pyrazoles, Oxadiazoles and Isoxazole Bearing Benzofuran Moiety. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp.248-253. ISSN 1996-840X.

The synthesis of novel derivatives of pyrazole-3-carboxylate (3-5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1)is reported. Synthesis of substituted 1,3,4-oxadiazoles (7-11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting from the 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, 1H NMR, 13C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gram-negative bacteria and a fungus.

Palavras-chave : 2,4-Dioxobutanoate; isoxazole; pyrazoles; pyrazole-3-carbohydrazide; 1,3,4-oxadiazoles.

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