SciELO - Scientific Electronic Library Online

 
vol.66One-Pot, Simple and Efficient Synthesis of Triaryl-1H-imidazoles by KMnO4/CuSO4Poly (Ethylene Glycol)-Bound Sulphonic Acid as a Novel Catalyst for Synthesis of Benzoxazoles author indexsubject indexarticles search
Home Pagealphabetic serial listing  

South African Journal of Chemistry

On-line version ISSN 1996-840X

Abstract

SIDDIQUI, Naqui-Jahan; IDREES, Mohammad; KHATI, N.T.  and  DHONDE, M. G.. Synthesis and Antimicrobial Activities of Some New Pyrazoles, Oxadiazoles and Isoxazole Bearing Benzofuran Moiety. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp. 248-253. ISSN 1996-840X.

The synthesis of novel derivatives of pyrazole-3-carboxylate (3-5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1)is reported. Synthesis of substituted 1,3,4-oxadiazoles (7-11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting from the 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, 1H NMR, 13C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gram-negative bacteria and a fungus.

Keywords : 2,4-Dioxobutanoate; isoxazole; pyrazoles; pyrazole-3-carbohydrazide; 1,3,4-oxadiazoles.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License