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vol.66The Vibrational Spectra of the Boron Halides and Their Molecular Complexes. Part 14. Ab Initio Studies of the Boron Trifluoride-Nitrous Acid ComplexA Structural Investigation of the D2O Solvated, Acetone Solvated and Nonsolvated 1,4-Diazabicyclo[2.2.2]octane Complexes of the Half Sandwich Moiety [(η5-C5H5)(CO)2Fe] índice de autoresíndice de assuntospesquisa de artigos
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South African Journal of Chemistry

versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350


HAMANN, Anton R. et al. Synthesis of Triazole-linked 2-Trichloromethylquinazolines and Exploration of Their Efficacy Against P falciparum. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp.231-236. ISSN 1996-840X.

Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration.

Palavras-chave : Malaria; 2-trichloromethylquinazoline; copper click chemistry; 1,2,3-triazole.

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