South African Journal of Chemistry
On-line version ISSN 1996-840X
HAMANN, Anton R. et al. Synthesis of Triazole-linked 2-Trichloromethylquinazolines and Exploration of Their Efficacy Against P falciparum. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp. 231-236. ISSN 1996-840X.
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration.
Keywords : Malaria; 2-trichloromethylquinazoline; copper click chemistry; 1,2,3-triazole.