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South African Journal of Chemistry

On-line version ISSN 1996-840X

Abstract

KINFE, Henok H.  and  BELAY, Yonas H.. Synthesis and biological evaluation of novel thiosemicarbazone-triazole hybrid compounds as antimalarial agents. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp. 00-00. ISSN 1996-840X.

A novel series of thiosemicarbazone-triazole hybrids were efficiently synthesized and evaluated for their activity against the 3D7 strain of the malaria parasite, Plasmodium falciparum. Although the hybrids were found not to be as potent as the standard chloroquine, they have shown activities interesting enough to warrant future structure activity relationship (SAR) studies.

Keywords : Thiosemicarbazone; triazole; hybrid; antimalarial.

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