South African Journal of Chemistry
On-line version ISSN 1996-840X
BROMLEY, Candice L. et al. Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp. 00-00. ISSN 1996-840X.
The known 3,6-dibromoindole (1), 6-bromo-3-chloroindole (2) and 6-bromo-2-oxindole (3) were isolated from the marine ascidian (sea squirt) Distapia skoogi collected from Algoa Bay, South Africa. Standard spectroscopic techniques were used to elucidate the structures of 1-3. All three compounds were found to be moderately cytotoxic to metastatic MDA-MB-231 breast cancer cells.
Keywords : Distaplia skoogi; ascidian; indole; oxindole.