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South African Journal of Chemistry

versão On-line ISSN 1996-840X


EBRAHIMLO, Ali Reza Molla. The facile synthesis of N-aryl isoxazolones as DNA intercalators under solvent-free conditions using microwave irradiation. S.Afr.j.chem. (Online) [online]. 2012, vol.65, pp. 104-107. ISSN 1996-840X.

The reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (I) elimination of the nitrogen gas (N2), (II) solvent-free conditions, (III) microwave irradiation, (IV) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.

Palavras-chave : Isoxazolones; N-aryl isoxazolones; solvent-free; 2-chlorobenzoxazole; 2-chlorobenzothiazole.

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