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South African Journal of Chemistry

On-line version ISSN 1996-840X

Abstract

RAMOS, Josierika A. Ferreira; NAGEM, Tanus J.  and  TAYLOR, Jason G.. Expedient access to an N-phenylpyrrolidin-2-yl heterocycle via a base-induced intramolecular aza-Michael reaction. S.Afr.j.chem. (Online) [online]. 2011, vol.64, pp. 225-230. ISSN 1996-840X.

Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-Michael reaction.

Keywords : aza Michael; intramolecular; catalysed; piperidine; pyrrolidine; base.

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