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South African Journal of Chemistry

versão On-line ISSN 1996-840X

Resumo

WU, Ming Shu; HE, Ping  e  ZHANG, Xiang Zhu. An environmentally friendly solvent-free synthesis of 3,4-dihydropyrimidinones using a p-aminobenzene sulfonic acid catalyzed Biginelli reaction. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp. 224-226. ISSN 1996-840X.

Anhydrous p-aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidi-nones by the cyclocondensation of aldehydes, β-ketoesters and urea/thiourea. Yields obtained are significantly higher than those obtained utilizing classical Biginelli reaction conditions.

Palavras-chave : Anhydrous p-aminobenzene sulphonic acid; 3,4-dihydropyrimidinones; Biginelli reaction.

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