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South African Journal of Chemistry

versión On-line ISSN 1996-840X

Resumen

KAWTHEKAR, Rahul B. et al. Synthesis of (S)-3-aminoethyl-1,2,3,4-tetrahydroisoquinoline (TIQ-diamine) via the Mitsunobu protocol. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp. 195-198. ISSN 1996-840X.

The synthesis of (S)-3-Aminoethyl-1,2,3,4-tetrahydroisoquinoline (TIQ-diamine) was successfully achieved via the Mitsunobu protocol. The method from earlier reports utilizing aminolysis of commercially available TIQ-amino methyl ester, and reduction of the amide, proved to be inadequate for preparation of TIQ-diamines. The modified route requires three additional steps and consequently rendered three novel intermediates, which were furnished under mild conditions.

Palabras clave : Tetrahydroisoquinoline; TIQ-diamine; Mitsunobu reaction.

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