South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
AZAM, M. Afzal; SURESH, Bhojraj; KALSI, Sandip S. and SHINESH ANTONY, A.. Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp.114-122. ISSN 1996-840X.
Several 2-mercaptobenzothiazole derivatives containing 1,3,4-oxadiazoles, 1,2,4-triazoles and 1,3,4-thiadiazoles at the second position were synthesized. Some of these synthesized compounds were evaluated for their in vivo analgesic, anti-inflammatory, acute toxicity and ulcerogenic actions. Some of the tested compounds showed significant analgesic and anti-inflammatory activities. Two of the compounds showed significant gastrointestinal protection compared to the standard drug diclofenac sodium. The compounds were also tested for their in vitro antimicrobial activity with most displaying selective activity against the Gram-negative bacteria Pseudomonas aeruginosa. In the present investigation the tested compounds did not possess antifungal activity.
Keywords : 2-Mercaptobenzothiazoles; 1,3,4-oxadiazoles; 1,3,4-thiadiazoles; antimicrobial activity; anti-inflammatory activity.