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South African Journal of Chemistry

versión On-line ISSN 1996-840X

Resumen

ISLAM, Rafique Ul et al. The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp. 88-94. ISSN 1996-840X.

A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.

Palabras clave : Piperazine; cholesterol; conjugates; transfection; cationic lipoplexes.

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