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South African Journal of Chemistry

On-line version ISSN 1996-840X

Abstract

ISLAM, Rafique Ul et al. The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp. 88-94. ISSN 1996-840X.

A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.

Keywords : Piperazine; cholesterol; conjugates; transfection; cationic lipoplexes.

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