South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
ISLAM, Rafique Ul et al. The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp.88-94. ISSN 1996-840X.
A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.
Keywords : Piperazine; cholesterol; conjugates; transfection; cationic lipoplexes.