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South African Journal of Chemistry

versión On-line ISSN 1996-840X

Resumen

RANI, Archna; JAIN, Sapna; KUMAR, Rita  y  KUMAR, Anil. 1,5-bis (2-hydroxyphenyl)pent-1,4-diene-3-one: A lead compound for the development of broad-spectrum antibacterial agents. S.Afr.j.chem. (Online) [online]. 2010, vol.63, pp. 31-35. ISSN 1996-840X.

A systematic and comparative study has been made starting from a naturally-occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (lc)asalead compound with potential against a panel of pathogenic bacterial strains, Staphylococcus (coagulase negative), Escherichia coli, Pseudomonas aeruginosa, Acenetobacter sp. and Klebsiella pneumoniae. Gentamycine and tetracycline were used as reference drugs. The mode of antibacterial action of 1c was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. In vitro toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.

Palabras clave : Chalcone; antibacterial agent; MIC; α ,β-unsaturated carbonyl compounds.

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