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South African Journal of Chemistry

versión On-line ISSN 1996-840X


EL-ZAHAR, Magdy I.; ABD EL-KARIM, Somaia S.  y  ANWAR, Manal M.. Synthesis and cytotoxicity screening of some novel benzofuranoyl-pyrazole derivatives against liver and cervix carcinoma cell lines. S.Afr.j.chem. (Online) [online]. 2009, vol.62, pp. 189-199. ISSN 1996-840X.

A series of new pyrazole, thiazole and thiazolinone derivatives incorporated into benzofuran were synthesized by using 3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-carboxaldehyde as starting material. A total of 41 novel compounds were synthesized. Some of these synthesized compounds were evaluated for cytotoxicity activity against HEPG2 (liver carcinoma cell line) and HELA (cervix carcinoma cell line). The tested compounds (1, 2c, 7c, 8b, 9b, 13b and 14b) showed better activities at low concentration against the commonly used human carcinoma cell lines. A detailed synthesis, spectroscopic data and cytotoxicity screening for the new compounds are described.

Palabras clave : Pyrazole; thiazolinone; benzofuran; benzofuranoyl-pyrazoles; cytotoxic screening; HEPG2; HELA.

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