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South African Journal of Chemistry

versão On-line ISSN 1996-840X

Resumo

SINGH, Ram J.  e  SINGH, Dharmendra K.. Synthesis and biological activity of some Triazolothiadiazoles. S.Afr.j.chem. (Online) [online]. 2009, vol.62, pp. 105-108. ISSN 1996-840X.

The synthesis of a series of novel 3-pyridyl-6-aryl-s-triazolo[3,4-b]-[1,3,4]-thiadiazoles is described. Fourteen new compounds were synthesized and characterized by spectral and elemental analyses. Some compounds were screened for antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. Compounds containing aryl substituents at position 6 and the 1,2,4-triazole moiety at position 1 or 2 showed reasonable antibacterial activity.

Palavras-chave : 1,2,4-Triazole; thiadiazole; potassium dithiocarbazinate; hydrazine hydrate; antibacterial activity.

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