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South African Journal of Chemistry
versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350
Resumo
OBIKEZE, Kene C.; MCKENZIE, Jean M.; GREEN, Ivan R. e MUGABO, Pierre. Characterization and cardiovascular effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a diterpenoid isolated from Leonotis leonurus. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.119-122. ISSN 1996-840X.
A new diterpenoid, (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.
Palavras-chave : Leonotis leonurus; diterpenoid; NMR analysis; chronotropic effect.