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South African Journal of Chemistry

On-line version ISSN 1996-840X

Abstract

OBIKEZE, Kene C.; MCKENZIE, Jean M.; GREEN, Ivan R.  and  MUGABO, Pierre. Characterization and cardiovascular effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a diterpenoid isolated from Leonotis leonurus. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp. 119-122. ISSN 1996-840X.

A new diterpenoid, (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.

Keywords : Leonotis leonurus; diterpenoid; NMR analysis; chronotropic effect.

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