Resumo

REDDY, Sanapalli S.; RAVI SANKAR, A.U.; NAGA RAJU, C.  e  KOTESWARA RAO, V.. Synthesis and antimicrobial activity of new α-aminophosphonic acid esters. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.97-101. ISSN 1996-840X.

Synthesis of new a-aminophosphonic acid esters (3a-I) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-I) were established by elemental analysis, and IR, ¹H, ¹³C, ³¹P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.

Palavras-chave : Phenyl glycine ethyl ester; aryl aldehydes; diethyl/dimethylphosphite; antimicrobial activity.

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