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South African Journal of Chemistry

versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350

Resumo

REDDY, Sanapalli S.; RAVI SANKAR, A.U.; NAGA RAJU, C.  e  KOTESWARA RAO, V.. Synthesis and antimicrobial activity of new α-aminophosphonic acid esters. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.97-101. ISSN 1996-840X.

Synthesis of new a-aminophosphonic acid esters (3a-I) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-I) were established by elemental analysis, and IR, 1H, 13C, 31P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.

Palavras-chave : Phenyl glycine ethyl ester; aryl aldehydes; diethyl/dimethylphosphite; antimicrobial activity.

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