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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350


REDDY, Sanapalli S.; RAVI SANKAR, A.U.; NAGA RAJU, C.  and  KOTESWARA RAO, V.. Synthesis and antimicrobial activity of new α-aminophosphonic acid esters. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.97-101. ISSN 1996-840X.

Synthesis of new a-aminophosphonic acid esters (3a-I) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-I) were established by elemental analysis, and IR, 1H, 13C, 31P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.

Keywords : Phenyl glycine ethyl ester; aryl aldehydes; diethyl/dimethylphosphite; antimicrobial activity.

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