SciELO - Scientific Electronic Library Online

vol.61The binary boron trifluoride-hydroxylamine molecular complex: N-bound or O-bound?Silica sulphuric acid as an efficient catalyst for the catalytic and metal-free oxidation of aromatic amines to their corresponding nitro compounds with sodium perborate under micellar media índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados



Links relacionados

  • En proceso de indezaciónCitado por Google
  • En proceso de indezaciónSimilares en Google


South African Journal of Chemistry

versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350


WAGENER, Judith M. et al. Modelling of the blood plasma species of biguanide derivatives exhibiting potential as diagnostic radiopharmaceuticals. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.82-92. ISSN 1996-840X.

99mTc-DMSA (DMSA=dimercaptosuccinic acid), the gold standard for static renal imaging, has a long uptake time, which is a limiting factor in diagnostic procedures and also leads to a relatively high radiation dose to patients. The ligands dimethyl biguanide (DMBG), biuret (BIU), 2-imino-4-thiobiuret (ITB) and carboxy-biguanide (CBIG) have nitrogen donor atoms, which are able to complex transition elements. The formation constants needed in order to establish a blood plasma model for these ligands were determined by potentiometry and the results are reported herein. Based on blood plasma modelling, it was shown that the ligands had selectivity for 99mTc over blood plasma metal ions at physiological pH and it was therefore hypothesized that the Tc-ligand complex would survive in blood plasma. Furthermore, no or few side effects related to the mobilization of blood plasma metal ions by these ligands are expected, once the radiopharmaceutical has been administered. It is also expected that these ligands should clear rapidly from the blood plasma.

Palabras clave : Biguanides; kidney agents; stability formation constants; blood plasma speciation; CBIG; DMBG; BIU; ITB.

        · texto en Inglés     · Inglés ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons