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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350


RAUF, Abdul; GANGA, Saloni; SHARMA, Shweta  and  ZAHIN, Maryam. A simple, rapid and efficient one-pot protocol for the synthesis of 2-substituted benzothiazole derivatives and their antimicrobial screening. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.63-67. ISSN 1996-840X.

A rapid and efficient condensation reaction of 2-aminothiophenol with various fatty acids in solvent-free conditions with or without microwave irradiation was carried out to afford the corresponding 2-substituted benzothiazole derivatives in good to excellent yields. The structures of the new products were established by elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited good antimicrobial activity.

Keywords : Fatty acids; 2-substituted benzothiazole; 2-aminothiophenol; antimicrobial activity; microwave irradiation.

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