South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
NARAJJI, Chandrashekhar; KARVEKAR, Manohar D. and KUMAR, A. Das. Synthesis and antioxidant activity of 3,3'-diselanediylbis (N,N-disubstituted indolizine-1-carboxamide) and derivatives. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.53-55. ISSN 1996-840X.
A series of novel diselenides 5a-e were synthesized from α-haloketones, α-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH.). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1-carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from a-picoline and chloroacetic acid by using the Tschischibabin reaction.
Keywords : Antioxidants; diselenides; indolizine; free radical scavenger; 1,1-DPPH.