Resumo

MAHARAJ, Y  e  NAIDOO, V G. Diagnosis and presenting features of autoimmune hepatitis at a central referral hospital in South Africa. SAMJ, S. Afr. med. j. [online]. 2024, vol.114, n.4, pp.46-51. ISSN 2078-5135.  http://dx.doi.org/10.7196/SAMJ.2024.v114i4.1646.

BACKGROUND: Autoimmune hepatitis (AIH) has scarcely been reported on in patients of black African descent. Similarly, few studies have focused on the relationship between AIH and HIV infection OBJECTIVE: To describe the presenting features of AIH from a single referral centre in a sub-Saharan African setting. We also compare the clinical and biochemical features of people with HIV to people without HIV METHODS: This study was a retrospective chart review. Patients were included if they fulfilled criteria for the International AIH Group simplified score for probable or definite AIH, were >18 years old at inclusion, and attended the adult gastroenterology clinic at a central referral hospital in South Africa for the period 1 January 2015 to 31 December 2020 on at least two occasions RESULTS: Forty cases were included, of which 33 (82.5%) were female and 33 (82.5%) were black African. Median age at diagnosis was 26 years. A diagnosis of a coexistent autoimmune disease was made in 22.5% of patients, with systemic lupus erythematosus being the most common (12.5%). There were 16 people living with HIV, all of whom were female (p=0.03), with a significantly older age of disease onset compared with people without HIV (median age 38 v. 17.5 years, p<0.001 CONCLUSION: AIH is a disease most commonly affecting young females. Female sex and older age of onset is associated with AIH in people living with HIV

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