SciELO - Scientific Electronic Library Online

 
vol.109 issue10Approach to lymphoma diagnosis and management in South AfricaAn approach to the diagnosis and management of multiple myeloma author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • On index processSimilars in Google

Share


SAMJ: South African Medical Journal

On-line version ISSN 2078-5135
Print version ISSN 0256-9574

Abstract

HOUSTON, B L; RIMMER, E; ZARYCHANSKI, R  and  SEFTE, M. Laboratory testing in the evaluation of a monoclonal protein: A practical framework for interpretation. SAMJ, S. Afr. med. j. [online]. 2019, vol.109, n.10, pp.719-722. ISSN 2078-5135.  http://dx.doi.org/10.7196/samj.2019.v109il0.14314.

Monoclonal proteins are immunoglobulins secreted by identical but abnormal plasma cells that are clones of a parent cell. While routine screening in the absence of signs or symptoms of disease is not recommended, testing is indicated in the diagnostic work-up for multiple myeloma and other plasma cell disorders. When indicated, a serum protein electrophoresis with immunofixation and serum free light-chain assay should be performed to determine the type and quantity of monoclonal protein. Using a case-based approach, we highlight common misconceptions with monoclonal protein investigations, and suggest a practical framework for diagnostic interpretation.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License