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SAMJ: South African Medical Journal
versão On-line ISSN 2078-5135
versão impressa ISSN 0256-9574
Resumo
KIRUI, N e SOKWALA, A. A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab. SAMJ, S. Afr. med. j. [online]. 2016, vol.106, n.7, pp.689-691. ISSN 2078-5135. http://dx.doi.org/10.7196/samj.2016.v106i7.9856.
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder with no prevalence or incidence studies in sub-Saharan Africa. Acquired TTP has several causes, all of which lead to decreased activity of von Willebrand factor cleaving protease (ADAMTS13) due to autoantibodies that are directed towards ADAMTS13. We report a case of a 46-year-old man who presented with most of the classic clinical manifestations of TTP.