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SAMJ: South African Medical Journal

versão On-line ISSN 2078-5135

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PARRISH, A  e  BLOCKMAN, M. Starch safety in resuscitation - when will we ever learn?. SAMJ, S. Afr. med. j. [online]. 2013, vol.103, n.6, pp. 365-367. ISSN 2078-5135.

Recent trials have failed to demonstrate a survival benefit from the use of hydroxyethyl starches (HES) as a colloid in fluid resuscitation and have raised concerns of renal harm. In severe sepsis, there is a concerning signal of increased mortality. New high-quality systematic reviews consistently demonstrate a statistically non-significant relative risk of death of 1.08 - 1.10 and a significant 25% increased chance of requiring renal replacement therapy. The HES literature contains many industry-affiliated reviews of indifferent quality. Traditional efficacy confidence limits may warrant re-evaluation when considering these harms. Newer formulations of HES and more focused indications for use show benefit on surrogate endpoints, but these trials are currently underpowered to ensure safety.

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