SAMJ: South African Medical Journal
versión On-line ISSN 2078-5135
MENDELSON, M et al. Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.12, pp. 924-926. ISSN 2078-5135.
Sirolimus, a potent inhibitor of B- and T-cell activation, is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus