SciELO - Scientific Electronic Library Online

vol.102 número6 índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

SAMJ: South African Medical Journal

versão On-line ISSN 2078-5135


OPIE, Lionel H. Cardioprotection from metabolism to molecules to certainties. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.6, pp. 491-492. ISSN 2078-5135.

Starting millions of years ago, the heart developed metabolic and molecular cardioprotective paths. The concept of metabolic protection includes the recent successful early provision of glucose-insulin-potassium (GIK) to patients with acute coronary syndromes in the ambulance to inhibit high harmful free-fatty acid levels. Molecular cardioprotective pathways also developed in primeval times. The 2 major paths are the RISK (Reperfusion Injury Salvage Kinases) path and the SAFE (Survival Activating Factor Enhancement) path, on which our group in Cape Town has focused. These paths help to lessen ischaemic-perfusion damage, and may, hypothetically, also be activated by intense exercise.

        · texto em Inglês     · pdf em Inglês