SciELO - Scientific Electronic Library Online

 
vol.102 issue6Biomedical engineering at the University of Cape Town: challenges and opportunitiesShedding the load of hypertension: The proteolytic processing of angiotensin-converting enzyme author indexsubject indexarticles search
Home Pagealphabetic serial listing  

SAMJ: South African Medical Journal

Print version ISSN 0256-9574

Abstract

WARNER, Digby F  and  MIZRAHI, Valerie. Approaches to target identification and validation for tuberculosis drug discovery: A University of Cape Town perspective. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.6, pp. 457-461. ISSN 0256-9574.

Tuberculosis (TB) disproportionately affects a few high-burden countries including South Africa. In these regions, basic TB research is rare, endemic countries being valued primarily as sites for drug trials and clinical studies. Our basic mycobacterial research focuses on current approaches to drug target identification and validation within the context of international trends in TB drug discovery. Increased funding for TB drug development globally prompted a significant shift in the composition of drug discovery consortia, with academic laboratories assuming a major role in collaboration with industrial partners. This hybrid model holds promise for the expansion of local programmes, especially where actively supported by government. However, the application of industry-standard business practices to research projects involving biology and chemistry expertise demands a greater appreciation of the differences between a chemically, versus biologically, validated drug target, and of the factors informing these differences.

        · text in English     · pdf in English