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    SAMJ: South African Medical Journal

    versão impressa ISSN 0256-9574

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    SOKWALA, Ahmed; MAHESH, V Shah; DEVANI, Smita  e  YONGA, Gerald. Helicobacter pylori eradication: a randomised comparative trial of 7-day versus 14-day triple therapy. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.6, pp. 368-371. ISSN 0256-9574.

    BACKGROUND: Helicobacter pylori is associated with several upper gastrointestinal conditions including chronic gastritis, peptic ulcer disease, and gatric malignancy. Proton pump inhibitor-based triple therapies are considered the standard regimens for H. pylori eradication, but the optimal duration of therapy is controversial. To prevent infection and complications, local studies should be undertaken to evaluate H. pylori eradication rates in a country. OBJECTIVES: We compared 7-day and 14-day regimens to determine the optimum duration of triple therapy for H. pylori eradication. We undertook a prospective randomised comparative trial of 7-day and 14-day triple therapy regimen for H. pylori eradication at the Aga Khan University Hospital, Nairobi; 120 patients with dyspepsia and H. pylori infection were randomised to receive esomeprazole, amoxicillin and clarithromycin for either 7 days (EAC 7) or 14 days (EAC 14). Compliance and side-effects were assessed 2 weeks after the start of therapy and H. pylori eradication was assessed by stool antigen tests 4 weeks after treatment. RESULTS: Both the intention-to-treat (ITT; N=120) and per protocol (PP; N=97) analyses showed no significant differences between the eradication rates of EAC 7 (ITT 76.7%; PP 92%) and EAC 14 (ITT 73.3%; PP 93.6%) (ITT p=0.67; PP p=0.76). Poor compliance was reported in one patient in the EAC 14 group. The incidence of adverse events was comparable in the two groups. CONCLUSION: One-week and 2-week triple treatments for H. pylori eradication are similar in terms of efficacy, safety and patient compliance

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