SciELO - Scientific Electronic Library Online

 
vol.102 issue3Sharps disposal practices among diabetic patients using insulinAssisted reproductive technology in South Africa: first results generated from the South African Register of Assisted Reproductive Techniques author indexsubject indexarticles search
Home Pagealphabetic serial listing  

SAMJ: South African Medical Journal

Print version ISSN 0256-9574

Abstract

KOEN, Liezl et al. Chromosome 22q11 in a Xhosa schizophrenia population. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.3, pp. 165-166. ISSN 0256-9574.

Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is known of their prevalence in African subjects with schizophrenia. We screened 110 African Xhosa-speaking participants with schizophrenia for the presence of micro-deletions. As further verification for the presence or absence of 22q11 microdeletions, we screened 238 Xhosa schizophrenia patients and 240 healthy Xhosa individuals from a larger schizophrenia candidate 22q11 gene study using molecular analyses. Data from molecular and cytogenetic analyses confirmed the absence of 22q11 microdeletions in the Xhosa schizophrenia samples. Although the absence of chromosome 22q11 micro-deletions in this group of patients does not exclude the possibility that it may occur in Xhosa schizophrenia patients, we concluded an extremely low prevalence. Our findings suggest that unique susceptibility loci may be present in this group.

        · text in English     · pdf in English