SAMJ: South African Medical Journal
Print version ISSN 0256-9574
SYMONS, Gregory et al. A historical review of XDR tuberculosis in the Western Cape province of South Africa. SAMJ, S. Afr. med. j. [online]. 2011, vol.101, n.9, pp. 642-644. ISSN 0256-9574.
There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDRTB) treatment and the subsequent development of extensively drugresistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.