SAMJ: South African Medical Journal
On-line version ISSN 2078-5135
Print version ISSN 0256-9574
SMIT, Derrick P. Pharmacological testing in Horner's syndrome: a new paradigm. SAMJ, S. Afr. med. j. [online]. 2010, vol.100, n.11, pp.738-740. ISSN 2078-5135.
For more than three decades, topical cocaine has been used to confirm the diagnosis and hydroxyamphetamine to localise the causative lesion in oculosympathetic palsy or Horner's syndrome. More recently, other drugs have demonstrated the ability to point to the diagnosis or anatomical site. Apraclonidine and phenylephrine, given their similar diagnostic efficacy and increased availability, may have superseded cocaine and hydroxyamphetamine as firstline pharmacological testing agents in Horner's syndrome.